14-3-3 and aggresome formation: Implications in neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
The polyglutamine-containing neurodegenerative protein ataxin 3 (AT3) has deubiquitylating activity and binds ubiquitin chains with a preference for chains of four or more ubiquitins. Here we characterize the deubiquitylating activity of AT3 in vitro and show it trims/edits K48-linked ubiquitin chains. AT3 also edits polyubiquitylated (125)I-lysozyme and decreases its degradation by proteasomes...
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OBJECTIVE The highly conserved 14-3-3 proteins interact with key players involved in Parkinson's disease (PD) and other neurodegenerative disorders. We recently demonstrated that 14-3-3 phosphorylation is increased in PD models and that increased 14-3-3 phosphorylation reduces the neuroprotective effects of 14-3-3 proteins. Here, we investigated whether 14-3-3 phosphorylation is altered in post...
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ژورنال
عنوان ژورنال: Prion
سال: 2014
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.28123